Key figure
How often an early stop for benefit held up
A key finding from Bassler and colleagues in JAMA, 2010. They compared 91 clinical trials that stopped early for benefit with 424 trials on the same 63 questions that ran to completion. In 39 of the 63 questions, the completed trials showed no significant benefit. It is a strong reason to fix stopping rules before fielding a product study and to plan against a smaller effect than an early stop suggests.
Where this appears
What's in this key figure
62% of questions where the trials that ran to completion showed no significant benefitBassler and colleagues matched 91 trials stopped early for benefit with 424 that were not, across 63 questions.
Use this image
Free to use in your docs, decks and posts under CC BY 4.0, as long as you credit Koji with a link to this page. To embed it, paste this into your page:
<a href="https://www.koji.so/visuals/trials-stopped-early-benefit-failed-to-hold-stat"><img src="https://www.koji.so/visuals/trials-stopped-early-benefit-failed-to-hold-stat/trials-stopped-early-benefit-failed-to-hold-stat.png" alt="Stat card: in 62% of 63 questions, trials that were not stopped early found no significant benefit, after other trials had stopped early for benefit." width="1200" height="630" /></a>
<p>Source: <a href="https://www.koji.so/visuals/trials-stopped-early-benefit-failed-to-hold-stat">How often an early stop for benefit held up</a>, Koji</p>
